Enterobacter cloacae

The Pathogen

Enterobacter cloacae is a rod-shaped, flagellated, opportunistic pathogen that is often contracted during prolonged hospital stays, invasive procedures (including catheterization), treatment in hospital settings greater than two weeks and antibiotic treatment in the past 30 days. Resultant conditions include a wide range of infections, such as bacteremia, endocardtis, septic arthritis, osteomyelitis, skin and soft tissue infections, as well as respiratory and urinary tract infections.

Enterobacter cloacae is a facultatively anaerobic organism, with the ability to derive energy in both aerobic and anaerobic environments. This is a key factor in the ability of Enterobacter cloacae to adapt to various conditions and resist drugs such as ampicillin and cephalosporins. In the presence of these drugs in particular, the pathogen exhibits the capacity to mutate quickly and form additional strains of drug-resistant bacteria. This ability to adapt to its environment, coupled with notorious resistance to multiple drugs makes Enterobacter cloacae infections exceedingly difficult to manage, bringing with it a mortality rate of 20-46 percent.

The Problem

It is often advised that treatment protocols for Enterobacter infections avoid certain antibiotics, particularly third-generation cephalosporins, because of the resistant mutants that can swiftly appear. As such, rapid detection and identification of the pathogen is critical for effective and targeted treatment. Unfortunately, lengthy wait times for conventional cultures often take up to 24 hours or longer to return results. Because of the life-threatening nature of Enterobacter cloacae infections, empirical treatment with ineffective antibiotics might take place while physicians wait 24 hours for test results to confirm the presence of Enterobacter cloacae. This practice could potentially expose patients to ampicillin and cephalosporins and put the Enterobacter cloacae infection at risk of developing a mutation to resist those and other drugs.

The NanoLogix Solution- Live-threat microorganism detection in 5-6 hours

In contrast to the 24-hour wait time of conventional Petri cultures, NanoLogix rapid detection and identifcation of live-cell Enterobacter cloacae takes place in an average of 5 to 6 hours. This is 4.8 to 6 times faster than conventional methods, and more accurate and less expensive than PCR protocol. With such dramatically faster result times, NanoLogix gives physicians an ability to treat patients with targeted and effective treatments in a much shorter time frame, increasing the likelihood of patient recovery from infection caused by Enterobacter cloacae.

 

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